Chemoenzymatic Synthesis of Phosphatidyl-L-serine Hydroperoxide

Phosphatidyl serine and phosphatidic acid complex (PSPATM)

Chemoenzymatic Enantioselective Formal Synthesis of (-)-Gephyrotoxin-223

(-)-Gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized  in the presence  of Candida Antartica lipase.        

Complete fractionation of brain cephalin; isolation from it of phosphatidyl serine, phosphatidyl ethanolamine, and diphosphoinositide.

Brain cephalin (1) has been the name given to a fraction of brain phosphatides characterized by its solubility in ether and insolubility in ethyl alcohol. For many years it was assumed to be a single compound with the chemical structure of diacylglycerylphosphoryl ethanolamine. Work from this laboratory has shown brain cephalin to be a mixture (2). From it were separated two pure phosphatides; ...

Stereoselective Synthesis of L-Deoxyaltronojirimycin from L-Serine

(2S,3R)-3-Hydroxy-2-(hydroxymethyl)-3,6-dihydro-2H-pyridine 8, an important precursor for the synthesis of polyhydroxylated piperidine azasugars, has been prepared from L-serine. Highly stereoselective nucleophilic addition to amino aldehyde 5 gave the corresponding allylic alcohol 6 which proceeded to give dihydro-2H-piridine 7a via a Grubbs II catalyzed RCM. Stereoselective H-bond directed ep...

P-124: Association between Fertilization Rate and Externilization of Phosphatidyl Serine

Background: Externalization of PS (EPS) is considered as a sign of early apoptosis. In addition, EPS also occurs during capacitation and the acrosome reaction. During this study we aimed to evaluate the relationship between EPS and fertilization, embryo quality and pregnancy outcomes in couples who were candidates for ICSI. Materials and Methods: Semen samples (n = 43) were collected from infer...